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Faculty

Helen A. Baghdoyan

Helen A. BaghdoyanHelen A. Baghdoyan
Professor
Ph.D., University of Connecticut (1980)

Email: hbaghdoy@utk.edu
Phone (865) 974-3740

Key words: Rapid eye movement (REM) sleep, non-REM sleep, wakefulness, general anesthesia, cognitive dysfunction, in vivo microdialysis


Research Interests

Neurochemical regulation of sleep and wakefulness, mechanisms of general anesthesia, mechanisms underlying the relationship between sleep disruption and psychiatric disorders

Research statement

My research program aims to identify the neurochemical mechanisms and brain regions that regulate behavioral states such as sleep, wakefulness, and anesthesia.  The goals of my laboratory are to identify overlapping neuronal circuits regulating the interactions between sleep, anesthesia, mood, cognition, and pain.  The work focuses on acetylcholine, GABA, and hypocretin/orexin as neurotransmitters, and the pontine reticular formation, basal forebrain, and prefrontal cortex as brain regions important for behavioral state control.

  • 2003      Invited Lecturer, APSS 17th Annual Meeting, 50th Anniversary of the Discovery of REM Sleep
  • 2004 - 2014   MERIT Award, National Institute of Mental Health
  • 2005      Department of Anesthesiology Basic Science Research Award
  • 2007      Department of Anesthesiology Basic Science Research Award
  • 2012      Invited Lecturer, APSS 26th Annual Meeting
  • 2013      Michigan Institute for Clinical & Health Research (MICHR) Distinguished Clinical and Translational Research Mentor Award
  • 2014      Beaman Professor, University of Tennessee, Knoxville

Current

  • National Institute of Mental Health Grant #5 R37 MH45361, "Cholinergic Mechanisms of REM Sleep Generation," Project Years 22-26, 1 March 2009 to 31 January 2014; no-cost extension to 31 January 2015; Direct Costs, $1,165,384; Total Costs, $1,800,519; Principal Investigator (50% effort)
  • National Heart, Lung, and Blood Institute Grant #1 R01 HL065272, "Cholinergic Phenotype in Murine Models of Sleep," Project Years 09-12, 1 July 2011 to 30 June 2014; no-cost extension to 30 June 2015; Direct Costs, $900,000; Total Costs, $1,389,268; Co-Investigator (20% effort) [Principal Investigator: R. Lydic]

Completed

  • National Institute of Mental Health Grant #5 R37 MH45361, "Cholinergic Mechanisms of REM Sleep Generation," Project Years 17-21, 1 May 2004 to 28 February 2009; Direct Costs, $1,125,000; Principal Investigator (50% effort)
  • National Institute of Mental Health Grant #2 R01 MH45361, "Cholinergic Mechanisms of REM Sleep Generation," Project Years 06-16, 1 September 1994 to 30 April 2004; Direct Costs, $2,212,374; Principal Investigator (50% effort)
  • National Institute of Mental Health (FIRST Award) Grant #1 R29 MH45361, "Cholinergic Mechanisms of REM Sleep Generation," Project Years 01-5, 1 September 1989 to 31 August 1994; Direct Costs, $350,000, Principal Investigator (50% effort)
  • National Heart, Lung, and Blood Institute Grant #R01 HL57120, "Opioid-Induced REM Sleep Inhibition," Project Years 01-10, 1 August 1997 to 30 June 2006: Direct Costs, $1,754,493; Co-Investigator (25% effort) [Principal Investigator: R. Lydic]
  • National Heart, Lung, and Blood Institute Grant #1 R01 HL065272, "Cholinergic Phenotype in Murine Models of Sleep," Project Years 01-09, 30 September 1999 to 31 August 2007; Direct Costs, $1,385,000; Co-Investigator (25% effort) [Principal Investigator: R. Lydic]

Recent Peer Reviewed

  • Filbey W, Sanford D, Baghdoyan HA, Koch LG, Britton SL, Lydic R.  Eszopiclone and dexmedetomidine depress ventilation in obese rats with features of metabolic syndrome.  Sleep 37:871-880, 2014.  PMID: 24790265 [PubMed – in process].
  • Hambrecht-Wiedbusch VS, Mitchell MF, Firn KA, Baghdoyan HA, and Lydic R.  Benzodiazepine site agonists differentially alter acetylcholine release in rat amygdala.  Anesthesia & Analgesia 118:1290-1300, 2014.  PMCID: PMC4054928 [Available on 2015/6/1].
  • Vanini G, Nemanis K, Baghdoyan HA, and Lydic R.  GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.  European Journal of Neuroscience 40:2264-2273, 2014.  PMID: 24674578 [PubMed – as supplied by publisher].
  • Watson SL, Watson CW, Baghdoyan HA, Lydic R.  Adenosine A1 receptors in mouse pontine reticular formation modulate nociception only in the presence of systemic leptin.  Neuroscience 275:531-539, 2014.  PMID: 24976513 [PubMed - as supplied by publisher]
  • Garrity AG, Botta S, Lazar SB, Swor E, Vanini G, Baghdoyan HA, Lydic R.  Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat.  Sleep, in press, 2014.  http://www.journalsleep.org/AcceptedPapers/SP-859-13_1.pdf
  • Gettys GG, Liu F, Kimlin E, Baghdoyan HA, and Lydic R.  Adenosine A1 receptors in mouse pontine reticular formation depress breathing, increase anesthesia recovery time, and decrease acetylcholine release.  Anesthesiology 118:327-336, 2013.  PMCID: PMC3553235
  • Vanini G and Baghdoyan HA.  Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness.  Sleep 36:337-343, 2013.  PMCID: PMC3571742
  • Wathen AB, West ES, Lydic R, and Baghdoyan HA.  Olanzapine causes a leptin-dependent increase in acetylcholine release in mouse prefrontal cortex. Sleep 35:315-323, 2012.  PMCID: PMC3274332
  • Vanini G, Lydic R, Baghdoyan HA. GABA-to-ACh ratio in basal forebrain and cerebral cortex varies significantly during sleep.  Sleep 35:1325-1334, 2012.  PMCID: PMC3443758
  • Vanini G, Wathen BL, Lydic R, Baghdoyan HA.  Endogenous GABA levels in the pontine reticular formation are greater during wakefulness than during REM sleep Journal of Neuroscience 31:2649-2656, 2011.  PMCID: PMC3073841
  • Watson CJ, Lydic R, and Baghdoyan HA. Sleep duration varies as a function of glutamate and GABA in rat pontine reticular formation.  Journal of Neurochemistry 118:571-580, 2011.  PMCID: PMC3144159
  • Gauthier EA, Guzick SE, Brummett CM, Baghdoyan HA, and Lydic R.  Buprenorphine disrupts sleep and decreases adenosine concentrations in sleep-regulating brain regions of Sprague Dawley rat.  Anesthesiology 115:743-753, 2011.  PMCID: PMC3197808
  • Watson SL, Watson CJ, Baghdoyan HA, and Lydic R.  Thermal nociception is decreased by hypocretin-1 and an adenosine A1 receptor agonist microinjected into the pontine reticular formation of Sprague Dawley rat.  The Journal of Pain 11:535-544, 2010.  PMCID: PMC2879477
  • Hambrecht-Wiedbusch VS, Gauthier EA, Baghdoyan HA, and Lydic R.  Benzodiazepine receptor agonists cause drug-specific and state-specific alterations in EEG power and acetylcholine release in rat pontine reticular formation.  Sleep 33:909-918, 2010.  PMCID: PMC2894433
  • Brevig HN, Watson CJ, Lydic R, and Baghdoyan HA.  Hypocretin and GABA interact in the pontine reticular formation to increase wakefulness.  Sleep 33:1285-1293, 2010.  PMCID: PMC2941414
  • Flint RR, Chang T, Lydic R, and Baghdoyan HA.  GABAA receptors in the pontine reticular formation of C57BL/6J mouse modulate neurochemical, electrographic, and behavioral phenotypes of wakefulness.  Journal of Neuroscience 30:12301-12309, 2010.  PMCID: PMC2952114
  • Muncey AR, Saulles AR, Koch LG, Britton SL, Baghdoyan HA, and Lydic R.  Disrupted sleep and delayed recovery from chronic peripheral neuropathy are distinct phenotypes in rat model of low aerobic capacity.  Anesthesiology 113:1176-1185, 2010.  PMCID: PMC2962768

Recent Invited Chapters and Reviews

  • Brevig HN and Baghdoyan HA.  Neurotransmitters and neuromodulators regulating sleep and wakefulness.  In:  Encyclopedia of Behavioral Neuroscience, volume 3, edited by GF Koob, M Le Moal, and RF Thompson, Academic Press, Oxford, pp 456-463, 2010.
  • Watson CJ, Baghdoyan HA, and Lydic R. REM sleep regulation by cholinergic neurons: Highlights from 1999 to 2009.  In:  Rapid Eye Movement Sleep – Regulation and Function, edited by BN Mallick, SR Pandi-Perumal, RW McCarley, and AR Morrison, Cambridge University Press, pp 194-205, 2011.
  • Vanini G, Lydic R, and Baghdoyan HA. GABAergic modulation of REM sleep.  In:  Rapid Eye Movement Sleep – Regulation and Function, edited by BN Mallick, SR Pandi-Perumal, RW McCarley, and AR Morrison, Cambridge University Press, pp 206-213, 2011.
  • Vanini G, Torterolo P, Baghdoyan HA, and Lydic R.  The shared circuits of sleep and anesthesia.  In:  The Neuroscientific Foundations of Anesthesiology, edited by GA Mashour and R Lydic, Oxford, pp 33-44, 2011.
  • Baghdoyan HA and Lydic R.  The neurochemistry of sleep and wakefulness.  In:  Basic Neurochemistry, edited by ST Brady, RW Albers, DL Price, and GJ Siegel.  Elsevier, pp 982-999, 2012.

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