Ph.D., Texas Tech University
Phone (865) 974-3740
Key words: Neurochemistry, states of consciousness, pain, regulation of respiration
My research program aims to help understand the cellular and neurochemical mechanisms regulating states of consciousness and state-dependent changes in physiology.
The goals of Lydic's research are elucidating the mechanisms by which sleep, opioids, and volatile anesthetics modulate pain and depress breathing and arousal. The evolutionary perspective and current data support the view that neurons generating sleep and wakefulness preferentially modulate the ability of opioids, hypnotics, and anesthetics to alter pain, behavioral affect, and states of waking consciousness.
- Past President, North American Sleep Research Society
- Julien F. Biebuyck Endowed Professor of Anesthesia, The Pennsylvania State University, College of Medicine
- Bert La Du Endowed Professor of Anesthesiology, University of Michigan
- Distinguished Alumni Award, Graduate School of Biomedical Sciences, Texas Tech Univ.
- Excellence in Research Award, American Society of Anesthesiologists
- Past Chairman, Advisory Council, National Space Biomedical Research Inst., Houston, TX
- Past Chairman, Advisory Panel, Institute of Circulatory and Respiratory Health, Canadian Institute of Health
- 2015- Scientific Advisory Committee, Canadian Sleep & Circadian Network
- 2016 Collaborative Scholarship and Research Award, University of Tennessee
- 2016-2019 Visiting Professor, Peoples Liberation Army Hospital, Beijing, China
- National Heart, Lung, and Blood Institute Grant #1 R01 HL065272, "Cholinergic Phenotype in Murine Models of Sleep," Project Years 09-12, 1 July 2011 to July 2017; Total Costs, $1,389,268; Co-Investigator.
- Lydic, R. (P.I.) Cholinergic mechanisms of breathing during sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-40881). Competing Renewal Application 2012 scored at 13th percentile. NHLBI funded to 11th the percentile.
- Lydic, R. (P.I.) Cholinergic mechanisms of breathing during sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-40881). Competing Renewal Application funded 01 December 2006 through 31 December, 2011. Award total $1,880,086.
- Lydic, R. (P.I.) Cholinergic mechanisms of breathing during sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-40881; 01-03). 1 July 1989 through June, 1992. Direct cost amount approved before N.I.H. financial adjustments: $334,453.00 Keifer, J. C. (P.I.),
- Lydic, R. (Research Mentor) Parker B. Frances Fellowship Program. Foundation for Anesthesia Education and Research. Young Investigator Award (J. C. Keifer) September 1991 to 31 August 1992: $66,000.
- Lydic, R. (P.I.) Small Instrumentation Grant Program. Heart, Lung, and Blood Institute of N.I.H. (1-S15-HL-47749). $13,641 for CCD Imaging System.
- Lydic, R. (P.I.) Cholinergic mechanisms of breathing during sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-40881; 04-07). Competing Renewal Application, Funded, July 1992 through April, 1996.
- Lydic, R. (P.I.) Cholinergic mechanisms of breathing during sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-40881; 08-11). Competing Renewal Application,
Funded 1 April 1996 through 30 April 2000. Direct cost amount approved before Congressionally directed financial adjustments: $835,651.
- Lydic, R. (P.I.) Opioid-induced REM sleep inhibition. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-57120). Funded 1 August 1997 through 2001. Direct cost amount approved before Congressionally directed financial adjustments: $704,594.
- Lydic, R. (Collaborating Investigator); J.K. Shoemaker (P.I.) Dean's Feasibility Grant 1998-1999: Interstitial Acetylcholine in Human Skeletal Muscle. Division of Cardiology, Department of Medicine, The Pennsylvania State University, College of Medicine. $25,000.
- Lydic, R. (P.I.) Cholinergic phenotype in murine models of sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-65272). Funded 30 September 1999 through 31 August 2003. Award total $983,480.
- Lydic, R. (P.I.) Cholinergic mechanisms of breathing during sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-40881). Competing Renewal Application funded 01 April 2000 through 31 March, 2006. Award total $1,468,529.
- Lydic, R. (P.I.) Opioid-induced REM sleep inhibition. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-57120). Competing Renewal Application funded 1 July 2001 through 30 June 2006. Award total $1,788,265.
- Lydic, R. (P.I.) Cholinergic phenotype in murine models of sleep. Heart, Lung, and Blood Institute of N.I.H. (R01 HL-65272). Competing Renewal Application funded 1 September 2003 through 31 August 2007. Award total $1,088,558.
- Lydic, R. (P.I.) Microdialysis delivery of Eszopiclone, Diazepam, and Zolpidem to rat pontine reticular formation effects on acetylcholine release, EEG power, breathing and arousal. November 2007 through November 2008. Sepracor Pharmaceutical.
- Lydic, R. (P.I.) Sleep: Neurobiology, Medicine and Society. University of Michigan Sleep Class. Education Grant number 31019 from Sanofi-Aventis USA, 4 June 2009 to 9 Sept 2009
O'Brien, C.B., Baghdoyan H.A., Lydic R. Computer-based multitaper spectrogram program for electroencephalographic data. Journal of Visualized Experiments. (153), e60333, DOI: doi:10.3791/60333 (2019). URL: https://www.jove.com/video/60333
Lu Y, Li Y-W, Wang L, Lydic R, Baghdoyan H.A., Shi X-Y, Zhang H. Sleep promotion is useful in preventing postoperative delirium: a systematic review and meta-analysis of randomized clinical trials. Sleep Medicine Reviews(In Press) 2019.
Blakeley-Ruiz, J., McClintock, C., Lydic, R., Baghdoyan, H.A., Choo, J., and Hettich, R. Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research. Behavioral and Brain Sciences,42, E66, 2019. doi:10.1017/S0140525X18002911
McLain JM, Alami WH, Glovak ZT, Cooley CR, Burke SJ, Collier JJ, Baghdoyan HA, Karlstad MD, Lydic, R. Sleep fragmentation delays wound healing in a mouse model of type 2 diabetes. SLEEP 41:(11) 1-9, 2018. doi:10.1093/sleep/zsy156. PMID:30107617
Bourdon AK, Spano G, Marshall W, Bellesi M, Tononi G, Serra PA, Baghdoyan HA, Lydic R, Campagna SR, Cirelli, C. Metabolomic analysis of mouse prefrontal cortex reveals upregulated analytes during wakefulness compared to sleep. Scientific Reports 8, 11225 (2018) doi:10.1038/s41598-018-29511-6
Angel C, Glovak ZT, Alami W, Mihalko S, Price J, Jiang Y, Baghdoyan HA, Lydic R. Buprenorphine depresses respiratory variability in obese mice with altered leptin signaling. Anesthesiology 128: 984-991,2018. PMCID 5903069
Lydic R, Baghdoyan, HA, May, AL. Neurochemistry of anesthetics states. Methods in Enzymology 603: 237-255, 2018. PMID 29673529
Glovak ZT, Mihalko S, Baghdoyan HA, Lydic, R. Leptin status alters buprenorphine induced antinociception in obese mice with dysfunctional leptin receptors. Neuroscience Letters 660: 29-33,2017 PMCID 5651198
Zhang H, Wheat H, Wang P, Jiang S, Baghdoyan HA, Neubig R, Shi X-Y, Lydic R. RGS proteins and Gαi2 modulate sleep, wakefulness, and disruption of sleep/wake states after isoflurane and sevoflurane anesthesia. SLEEP 39: 393-404, 2016. PMID:26564126
Garrity AG, Botta S, Lazar SB, Swor E, Vanini G, Baghdoyan HA, Lydic R. Dexmedetomidine-induced sedation does not mimic the neurobehavioral phenotypes of sleep in Sprague Dawley rat. Sleep 38: 73-84, 2015.
Filbey W, Sanford D, Koch LG, Britton SL, Baghdoyan HA, Lydic, R. Dexmedetomidine and eszopiclone depress ventilation in obese rats that have features of metabolic syndrome. Sleep 37: 871-880, 2014.
Hambrecht-Wiedbusch V, Mitchell MF, Firn KA, Baghdoyan HA, Lydic R. Benzodiazepine receptor agonists differentially alter acetylcholine levels in rat amygdala. Anesthesia and Analgesia 118:1293-300, 2014. PMC4054928
Vanini G, Nemanis K, Baghdoyan HA, Lydic R. GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation. European Journal of Neuroscience 40: 2264-2273, 2014. PMID:24674578
Watson SL, Watson CJ, Baghdoyan HA, Lydic, R. Adenosine A1 receptors in mouse pontine reticular formation modulate nociception only in the presence of systemic leptin. Neuroscience 275: 531-539, 2014.
Gettys GC, Liu F, Kimlin E, Baghdoyan HA, and Lydic R. Adenosine A1 receptors in mouse pontine reticular formation depress breathing, increase anesthesia recovery time, and decrease acetylcholine release. Anesthesiology 118: 327-336, 2013. PMCID: PMC3553235
Wathen AB, West ES, Lydic R, Baghdoyan HA. Olanzapine causes a leptin-dependent increase in acetylcholine release in mouse prefrontal cortex. Sleep 35: 315-323, 2012. PMCID: PMC3274332
Pal D, Walton M, Lipinski B, Lydic R, Koch LG, Britton SL, Mashour GA. Determination of minimum alveolar concentration for isoflurane and sevoflurane in a rodent model of human metabolic syndrome. Anesthesia and Analgesia 114: 297-302, 2012. PMCID: PMC3272881
Vanini G, Lydic R, Baghdoyan HA. GABA-to-ACh ratio in basal forebrain and cerebral cortex varies significantly during sleep. Sleep 35: 1325-1334, 2012. PMCID: PMC3443758
Vanini G, Wathen BL, Lydic, R, Baghdoyan HA. Endogenous GABA levels in the pontine reticular formation are greater during wakefulness than during REM sleep. Journal of Neuroscience 31: 2649-2656, 2011. *(Selected for "This week in the Journal) PMCID: PMC3073841
Brummett CM, Hong E, Janda AM, Amodeo FS, Lydic R. Perineural dexmedetomidine added to ropivacaine for sciatic nerve block in rats prolongs the analgesia duration by blocking hyperpolarization-activated cation current. Anesthesiology 115: 836-43, 2011. PMCID: PMC3179561
Gauthier EA, Guzick SE, Brummett CM, Baghdoyan HA, Lydic R. Buprenorphine disrupts sleep and decreases adenosine concentrations in sleep-regulating brain regions of Sprague Dawley rat. Anesthesiology 115: 743-53 2011. PMCID: PMC5197808
Watson CJ, Lydic, R, Baghdoyan HA. Glutamate and GABA in rat pontine reticular formation modulate sleep duration. Journal of Neurochemistry 118: 571-80, 2011. PMCID: PMC3144159
Watson SL, Watson CJ, Baghdoyan HA, Lydic R. Thermal nociception is decreased by hypocretin-1 and an adenosine A1 receptor agonist microinjected into the pontine reticular formation of Sprague Dawley rat. Journal of Pain 11: 535-544, 2010. PMCID: PMC2879477
Brown E, Lydic R, Schiff ND. General anesthesia, sleep, and coma. New England Journal of Medicine 363: 2638-2650, 2010. PMID: 21190458